BF3⋅OEt2‐Mediated Highly Stereoselective Synthesis of Trisubstituted‐Tetrahydrofuran via [3+2] Cycloaddition Reaction of 2‐Arylcyclopropyl Ketones with Aldehydes

Abstract

Abstract A one‐step [3+2] cycloaddition of vicinal‐substituted donor–acceptor cyclopropanes to aldehydes catalyzed by BF3⋅OEt2 leading to 2,3,5‐trisubstituted tetrahydrofurans has been developed. This methodology has advantages of broad substrate scope, good yields and high diastereoselectivity.