Ceria Nanoparticles that can Protect against Ischemic Stroke
- Chi Kyung Kim
- Taeho Kim
- In‐Young Choi
- Min Soh
- Dohoung Kim
- Young‐Ju Kim
- Hyunduk Jang
- Hye‐Sung Yang
- Jun Yup Kim
- Hong‐Kyun Park
- Seung Pyo Park
- Sangseung Park
- Taekyung Yu
- Byung‐Woo Yoon
- SLSeung‐Hoon Lee
- Taeghwan Hyeon
Angewandte Chemie International Edition · 2012 · Wiley
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Abstract
Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.