Mapping Human Genetic Diversity in Asia
- Mahmood Ameen Abdulla
- Ikhlak Ahmed
- Anunchai Assawamakin
- Jong Bhak
- Samir Kumar Brahmachari
- Gayvelline C. Calacal
- Amit Chaurasia
- Chien-Hsiun Chen
- Jieming Chen
- Yuan-Tsong Chen
- Jiayou Chu
- Eva Maria C. Cutiongco–de la Paz
- Maria Corazon A. De Ungria
- Frederick C. Delfin
- Juli Edo
- Suthat Fuchareon
- Ho Ghang
- Takashi Gojobori
- Junsong Han
- Sheng-Feng Ho
- Boon‐Peng Hoh
- Wei Huang
- Hidetoshi Inoko
- Pankaj Kumar Jha
- Timothy Adrian Jinam
- JLJin Li
- Jongsun Jung
- Daoroong Kangwanpong
- Jatupol Kampuansai
- Giulia Catignani Kennedy
- Preeti Khurana
- Hyung Lae Kim
- Kwang-Joong Kim
- Sangsoo Kim
- Woo-Yeon Kim
- Kuchan Kimm
- Ryosuke Kimura
- Tomohiro Koike
- Supasak Kulawonganunchai
- Vikrant Kumar
- Poh San Lai
- Jong‐Young Lee
- Sunghoon Lee
- Edison T. Liu
- Partha Pratim Majumder
- Kiran Kumar Mandapati
- Sangkot Marzuki
- Wayne A. Mitchell
- Mitali Mukerji
- Kenji Naritomi
- Chumpol Ngamphiw
- Norio Niikawa
- Nao Nishida
- Bermseok Oh
- Sang Ho Oh
- Jun Ohashi
- Akira Oka
- Rick Twee‐Hee Ong
- Carmencita David Padilla
- Prasit Palittapongarnpim
- Henry B. Perdigon
- Maude Elvira Phipps
- Eileen Png
- Yoshiyuki Sakaki
- Jazelyn M. Salvador
- Yuliana Sandraling
- Vinod Scaria
- Mark T. Seielstad
- Mohd Ros Sidek
- Amit Kumar Sinha
- Metawee Srikummool
- Herawati Sudoyo
- Sumio Sugano
- Helena Suryadi
- Yoshiyuki Suzuki
- Kristina A. Tabbada
- Adrian K.S. Tan
- Katsushi Tokunaga
- Sissades Tongsima
- Lilian Pagaduan Villamor
- Eric Wang
- Ying Wang
- Haifeng Wang
- Jer-Yuarn Wu
- Huasheng Xiao
- Shuhua Xu
- Jin Ok Yang
- Yin Yao Shugart
- Hyang Sook Yoo
- Wentao Yuan
- Guoping Zhao
- Bin Alwi Zilfalil
Science · 2009 · American Association for the Advancement of Science
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Abstract
Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.