Methyl Pyropheophorbide-aAnalogues: Potential Fluorescent Probes for the Peripheral-Type Benzodiazepine Receptor. Effect of Central Metal in Photosensitizing Efficacy
- Yihui Chen
- Xiang Zheng
- MDMahabeer Prasad Dobhal
- Amy Gryshuk
- Janet Morgan
- Thomas J. Dougherty
- Allan Roy Oseroff
- Ravindra Kumar Pandey
Journal of Medicinal Chemistry · 2005 · American Chemical Society
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Abstract
Pyropheophorbides and their metal complexes were synthesized to investigate their applications as nonradioactive peripheral benzodiazepine receptor (PBR) binding probes and photosensitizers for use in photodynamic therapy. They were found to be localized in mitochondria and showed significant binding to PBR. In some cases, the PBR binding values were similar to that for 17 (PK11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide). However, no direct correlation between 17 displacement ability and photosensitizing efficacy of photosensitizers was observed.