Proteogenomic Characterization of Endometrial Carcinoma
- Yongchao Dou
- Emily Kawaler
- Daniel Cui Zhou
- Marina A. Gritsenko
- Chen Huang
- Lili M. Blumenberg
- Alla Y. Karpova
- Vladislav Petyuk
- Sara R. Savage
- Shankha Satpathy
- Wenke Liu
- Yige Wu
- Chia‐Feng Tsai
- Bo Wen
- Zhi Li
- Song Cao
- Jamie Moon
- Zhiao Shi
- MacIntosh Cornwell
- Matthew A. Wyczalkowski
- Rosalie Chu
- Suhas Vasaikar
- Hua Zhou
- Qingsong Gao
- Ronald Moore
- Kai Li
- Sunantha Sethuraman
- Matthew Monroe
- RZRui Zhao
- David I. Heiman
- Karsten Krug
- Karl R. Clauser
- Ramani Kothadia
- Yosef E. Maruvka
- Alexander R. Pico
- Amanda E. Oliphant
- Emily L. Hoskins
- Samuel L. Pugh
- Sean J.I. Beecroft
- David W. Adams
- Jonathan C. Jarman
- Andy T. Kong
- Hui-Yin Chang
- Boris Reva
- Yuxing Liao
- Dmitry Rykunov
- Antonio Colaprico
- Xi Chen
- Andrzej Czekański
- Marcin Jędryka
- Rafał Matkowski
- Maciej Wiznerowicz
- Tara Hiltke
- Emily S. Boja
- Christopher R. Kinsinger
- Mehdi Mesri
- Ana I. Robles
- Henry Rodriguez
- David G. Mutch
- Katherine C. Fuh
- Matthew J. Ellis
- Deborah F. DeLair
- Mathangi Thiagarajan
- D.R. Mani
- Gad Getz
- Michael S. Noble
- Alexey I. Nesvizhskii
- Pei Wang
- Matthew L. Anderson
- Douglas A. Levine
- Richard Smith
- Samuel Payne
- Kelly V. Ruggles
- Karin Rodland
- Li Ding
- Bing Zhang
- TLTao Liu
- David Fenyö
- Anupriya Agarwal
- Meenakshi Anurag
- Dmitry M. Avtonomov
- Chet Birger
- Michael J. Birrer
- Simina M. Boca
- William Bocik
- Uma Borate
- Melissa Borucki
- Meghan C. Burke
- Shuang Cai
- Anna Calinawan
- Steven A. Carr
- Sonya Carter
- Patricia Castro
- Sandra Cerda
- Michelle Chaikin
- Daniel W. Chan
- Doug W. Chan
- Alyssa Charamut
- Feng Chen
- Jin Chen
- TLTao Liu
- RZRui Zhao
- RZRui Zhao
Cell · 2020 · Cell Press
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Abstract
We undertook a comprehensive proteogenomic characterization of 95 prospectively collected endometrial carcinomas, comprising 83 endometrioid and 12 serous tumors. This analysis revealed possible new consequences of perturbations to the p53 and Wnt/β-catenin pathways, identified a potential role for circRNAs in the epithelial-mesenchymal transition, and provided new information about proteomic markers of clinical and genomic tumor subgroups, including relationships to known druggable pathways. An extensive genome-wide acetylation survey yielded insights into regulatory mechanisms linking Wnt signaling and histone acetylation. We also characterized aspects of the tumor immune landscape, including immunogenic alterations, neoantigens, common cancer/testis antigens, and the immune microenvironment, all of which can inform immunotherapy decisions. Collectively, our multi-omic analyses provide a valuable resource for researchers and clinicians, identify new molecular associations of potential mechanistic significance in the development of endometrial cancers, and suggest novel approaches for identifying potential therapeutic targets.