Synthetic and antibacterial studies of rhodanine derivatives with indol-2,3-diones

Abstract

A facile synthesis of new isatylidene and quinoline derivatives is described by treatment of rhodanine with indol-2,3-diones via Knoevenagel condensation and Pfitzinger reaction respectively. The reaction of indol-2,3-dione derivatives with five membered heterocycles, viz rhodanine under normal and basic conditions is described. While refluxing with ethanol it afford 3,4-dihydro-3[2-thioxo-4 -thiazolidinoneJindol-2-one 3, under basic conditions l -methyl-2-thio-4-thiazolidino[5,4-b J quinoline-4-carboxylic acid 4 is obtained. The compounds 3 and 4 have been characterized by spectral studies and elemental analyses and screened for antibacterial activity.